雷火电竞app

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Research platforms
Non-clinical Pharmacokinetic Research Platform
In vitro pharmacokinetic study

Absorption research
-Cell permeability assay (caco-2 cells, MDCK cells)

Distribution research
-Plasma-based protein-binding assay
-Plasma distribution ratio test in whole blood
-Melanin-binding assay

Identification of metabolites
-Metabolite identification in hepatocytes / liver microsomes / liver S9 / kidney S9
-Identification of ADC drug metabolites in lysosomes and tumor cells
-Identification of metabolites in vivo (blood, urine, feces, bile, liver, kidney, brain, etc.)


Stability research
-Metabolic stability studies in hepatocytes / liver microsomes / liver S9 / kidney S9
-Plasma stability study
-And ADC plasma / serum stability
-DAR value determination

Drug interaction studies
-Reversible / time-dependent inhibition of CYP and UGT enzymes
-The CYP metabolic phenotype test
-The CYP enzyme induction assay
-ABC transporter assay (caco-2 cells)
-SLC transporter test (HEK293 cells)

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