A variety of general toxicology tests are performed to determine the maximum tolerability (MTD), dose range, and single/repeated-dose toxicity of a drug, along with other specialized tests like tissue crossover studies.

Test Types:
-Maximum tolerability (MTD) study
-Dose range determination test
-Single-dose toxicity test
-Repeated-dose toxicity test
-Others: Tissue crossover study (TCR), in vitro cytokine release, etc.

Routes of Administration:
-Oral, nasal, intravenous, subcutaneous, intradermal, intraperitoneal, intramuscular, and intratumoral injections.
-Skin application, transdermal patches, microneedle injections, CNS delivery techniques (e.g., fixed-point brain injection, ventricular injection, intrathecal injection), ophthalmic-related -Administration (e.g., eye drops, subconjunctival injections).
-Inhalation, local mucosal (oral, vaginal, rectum), and specialized injections (e.g., joint cavity, bladder irrigation, intracranial, transsplenic, and intervertebral disc injections).